Livedoid vasculitis
Livedoid vasculitis በአብዛኛው ከወጣት እስከ መካከለኛ ዕድሜ ላይ ባሉ ሴቶች ላይ የሚታይ ሥር የሰደደ የቆዳ በሽታ ነው። ባህሪያቱን ለመግለጽ አንድ ምህጻረ ቃል "የታችኛው ዳርቻዎች ሬቲኩላር ቅርፅ ያላቸው የሚያም የፐርፕዩሪክ ቁስሎች" (PurpLE) ነው። ሥር የሰደደ የደም ግፊት እና የ varicosities ጨምሮ ከበርካታ በሽታዎች ጋር የተያያዘ ነው.
☆ እ.ኤ.አ. በ 2022 ከጀርመን የስቲፍቱንግ ዋረንቴስት ውጤቶች ፣ በሞዴልደርም የተገልጋዮች እርካታ ከሚከፈልባቸው የቴሌሜዲኬን ምክሮች በትንሹ ያነሰ ነበር።
ከህመም ጋር አብሮ ሊሄድ ይችላል።
References
Livedoid vasculopathy በጣም አልፎ አልፎ የሚከሰት የቆዳ ህመም ሲሆን ህመም የሚያስከትሉ ቁስሎች ከታች እግሮች ላይ በተደጋጋሚ ይመለሳሉ።
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy በግርጌ እግር ላይ ተደጋጋሚ ቁስለት የሚያመጣ የቆዳ በሽታ ሲሆን ይህም አትሮፊ ብላንሽ በመባል የሚታወቁ ገርጣ ጠባሳዎችን ያስቀራል። ትክክለኛው መንስኤ እስካሁን ግልጽ ባይሆንም የደም መርጋት (hypercoagulability) መጨመር ዋነኛው ምክንያት እንደሆነ ይታመናል እብጠት ሁለተኛ ደረጃ ሚና ይጫወታል. ለደም መርጋት አስተዋጽኦ የሚያደርጉ ነገሮች የሚከተሉትን ያካትታሉ - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine ። ባዮፕሲ ውስጥ, ሁኔታው በመርከቦቹ ውስጥ የደም መርጋት, የመርከቧ ግድግዳዎች ውፍረት እና ጠባሳ ያሳያል. ሕክምናው እንደ ፀረ-ፕሌትሌት መድሐኒቶች፣ ደም ሰጪዎች እና ፋይብሪኖሊቲክ ሕክምና ባሉ መድኃኒቶች አማካኝነት የደም መርጋትን በመከላከል ላይ ያተኮረ ሁለገብ አካሄድን ያካትታል። ለዚህ የቆዳ ህመም የተለያዩ መድሃኒቶችን መጠቀም ይቻላል - colchicine and hydroxychloroquine, vasodilators, immunosuppressants ።
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy በሁለቱም እግሮች ላይ ቁስሎች የሚከሰትበት ያልተለመደ ሁኔታ ነው። በጥቃቅን የደም ስሮች ውስጥ የደም መርጋት መፈጠር የመርጋት መጨመር እና የመርጋት ስብራት በመቀነሱ እና በመርከቧ ሽፋን ላይ ከሚደርሰው ጉዳት ጋር ተያይዞ እንደሆነ ይታሰባል። በሴቶች ላይ በተለይም ከ15 እስከ 50 ዓመት ባለው ጊዜ ውስጥ በጣም የተለመደ ነው። ማጨስን ማቆም፣ ቁስሎችን መንከባከብ እና እንደ የደም ማነቃቂያ እና አንቲፕሌትሌት መድሐኒቶች ያሉ መድኃኒቶችን መጠቀም ውጤታማ ሆነዋል።
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
